منابع مشابه
SnapShot: Spliceosome Dynamics II
Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to regulate splicing. The majority of higher eukaryotic protein-coding genes contain more than one intron and the derived pre-mRNAs can be alternatively spliced. Diverse principles ensure the reliable identification of authentic splice sites while concomitantly providing flexibility in splice site ...
متن کاملSnapShot: Spliceosome Dynamics III
The complex compositional and conformational dynamics of spliceosomes required for regulated splicing are prone to malfunction when mutations affect splicing factors or cis-acting regulatory sequences. Indeed, many such mutations have been linked to heritable diseases or malignancies in humans. Small molecule modulators and antisense oligonucleotides or analogs harbor great potential for therap...
متن کاملSnapShot: Spliceosome Dynamics I
Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome. They are the prototypes of dynamic molecular machines, assembling de novo for each sp...
متن کاملSnapShot: Axon Guidance II
722 Cell 153, April 25, 2013 ©2013 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2013.04.004 SnapShot: Axon Guidance II Alex L. Kolodkin1 and R. Jeroen Pasterkamp2 1Department of Neuroscience, HHMI, The Johns Hopkins University School of Medicine, Baltimore, MD 21212, USA 2Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrech...
متن کاملSnapShot: Nuclear Receptors II
Estrogen-related receptors* ERRα/NR3B1; ERRβ/NR3B2; ERRγ/NR3B3 All major systems with specific isoforms showing peaks of expression in metabolic tissues (ERRα and ERRβ) and the CNS (ERRγ) Structurally homologous to estrogen receptors; bind EREs but not activated by estrogens; modulate the expression of enzymes involved in adipogenesis, energy metabolism, and synthesis of lipids, eicosanoids, an...
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ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.06.061